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Acute wound healing is a complex process which involves several cells and mediators. It is divided into three overlapping sequences which include hemostasis and inflammation, migration and proliferation and wound remodeling.
Platelets play a key role in clotting and hemostasis and release multiple growth factors which initiate the healing process. Monocytes and macrophages are important for transition to the migration and proliferative phase of wound healing. During this phase epithelialization, angiogenesis, and granulation tissue formation occur.
The remodeling phase of wound healing can take many months to occur. During this phase collagen remodeling occurs and the ratio of type three to type one collagen decreases.
Differential diagnosis and evaluation of chronic wounds
Laurel M. Morton, MD, Tania J. Phillips, MD, JAAD April 2016 Volume 74, Issue 4, Pages 589–605
Broughton G, et al. Plast Reconstr Surg. 2006;117:1e-S-32e-S